Diurnal Group Improving treatments for endocrine disorders

These include increased nitrogen retention, enhanced protein synthesis, increased IGF-1 production, improved libido levels, increased red blood cell production, and decreased levels of glucocorticoids. Richard has over 25 years’ experience in senior finance and strategic roles within the pharmaceutical and biotechnology sector. Richard is also a non-executive director of Cambridge Cognition Holdings and Chroma Therapeutics.

Operating expenses (excluding £0.3m COGS) for H121 were £6.72m and we expect these to increase in the latter half of the fiscal year as the company prepares for the commercial launch of Chronocort in Europe. We forecast operating expenses (excluding COGS) of £15.2m for the fiscal year and expect these to continue to expand, driven by marketing costs. We expect the company to achieve profitability in FY24 following the potential expansion of the indication for Chronocort in Europe to include adult AI. We also believe that there are strategic benefits in the launch of Alkindi as it serves as the beachhead for the later potential approval of Chronocort. Also if and once Chronocort is approved, Diurnal will be providing ‘cradle-to-grave’ treatment options for CAH sufferers which may also assist in marketing.

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Diurnal ended 2020 with £20.3m in cash following a Q420 fund-raise of £9.1m (net). We expect the company to need £25m in further capital to complete the development and launches of its lead products, which we record as illustrative debt in FY22. Our men’s health experts offer professional advice and treatment for steroid users without judgement. If you’re using anabolic steroids, let us help you reduce the negative impact they can have on your health — contact us for a no-obligation consultation at our confidential clinic.

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Like many other specialty pharmaceutical companies, Diurnal Group’s strategy has comparatively lower clinical risk than the development of new chemical entities. For instance, despite strong effect sizes, Diurnal’s prior Phase III clinical study for Chronocort failed to meet its primary endpoint. This being said the company has been able to file for European approval with the data from this study. However, we expect the majority of the hurdles that Diurnal will face to be commercial in nature.

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Sam has over 20 years’ experience in the biotechnology industry, both as a top-ranked equity analyst in the City and, subsequently, as an entrepreneur and chief executive. Sam is head of life sciences at IP Group and serves as executive chairman of Istesso; non-executive chairman of Microbiotica and Iksuda; and non-executive director of Genomics, Pulmocide and Psioxus Therapeutics. Sam has a PhD in molecular biology from Cambridge University and an MA in pure and applied biology from Oxford University. The company ended 2020 with £20.3m in cash, following a fundraise in October 2020 (£9.1m net proceeds).